Advanced Search Abstract Although microRNA miR is emerging as an oncogene and has been shown to target several tumor suppressor genes, including programmed cell death 4 PDCD4its precise mechanism of action on cancer stem cells CSCs is unclear. Recent evidence supports the contention that cancer is driven by a small set of self-renewing cells, termed cancer stem cells CSCswhich are distinct from the bulk of the cells in the tumor. Like normal stem cells, CSCs grow slowly and are more likely to survive chemotherapy than other cells.
In Western countries, breast cancer is the most common form of cancer and it is the second leading cause of female cancer death in America. The biochemical basis of the observed anti-oncogenic properties of green tea has been linked to the cellular effects of polyphenols found in the Camellia sinensis leaf.
In this study we obtained dose-response data for the cellular effects of Polyphenon 60 green tea extract on MCF-7 breast cancer cells.
The specific regulatory mechanism behind how polyphenols affect gene expression and cancer cell survival has yet to be identified but current data suggests that small, non-protein coding microRNAs miRNAs may be responsible.
This study further investigated the relationship between Polyphenon 60 dosage and miRNA responsiveness using let-7g, let-7e, miR, miRb, miRa, miRa, miRm, and miR, eight of the previously identified microarray miRNAs of interest.
Additionally, miRb, miRa, miR, and miRc were investigated based on previous reports of their connection to breast cancer. Time-dependent data was also generated for miRa, miRa, miRc, and miR following 24, 48, and 72 hour treatment with low and high dose Polyphenon 60 treatment.
At low-doses and short treatment times, miR and miRc were up-regulated and directly reversed their typical breast cancer expression. The subtle changes that low-dose green tea extract can induce in the miRNA expression profile of MCF-7 cells may help substantiate the previous epidemiological claims that green tea can influence breast cancer pathogenesis.Summary.
The radioresistance of esophageal squamous cell carcinoma is a great obstacle to treatment. Although it has been demonstrated that microRNA (miR) can act as an ‘oncogene’ in esophageal squamous cell carcinoma, its role in radioresistance remains unexplored. donors (asthma, breast cancer, colon cancer, and pneumonia).
IgG total concentrations were measured in 38 serum and plasma samples from normal and diseased donors (asthma, breast cancer, colon cancer, myeloma, pneumonia, sepsis, and B-cell chronic lymphocytic leukemia). Furthermore, our study revealed that the global upregulation of miR and downregulation of miRa in breast carcinogenesis could be reversed by 3,6-DHF, which significantly upregulated miRa expression and decreased miR expression - inducing apoptosis of breast cancer .
RNA interference (RNAi) is a biological process in which RNA molecules inhibit gene expression or translation, by neutralizing targeted mRNA molecules.
Historically, RNA interference was known by other names, including co-suppression, post-transcriptional gene silencing (PTGS), and grupobittia.com detailed study of each of these seemingly .
Jun 07, · MicroRNA (miR) has been reported as the potential novel diagnostic biomarker for breast cancer in several studies, but their results were inconsistent. Therefore, we conducted a systematic analysis to evaluate the diagnostic value of miR in detecting breast cancer.
Insufficient tissue oxygenation, or hypoxia, contributes to tumor aggressiveness and has a profound impact on clinical outcomes in cancer patients.